Henderson's ground and pound show gashed the Jacksonville defense all night, and when the final horn sounded at the Historic Tomato Bowl on Friday evening, the Lions had earned a 67-40 victory over the Tribe.
The homecoming loss dropped the Indians to 1-2, heading into the bye week.
Henderson upped its record to 2-1 and will host Center on Sept. 20.
The Lions scored seven rushing touchdowns, amassed 534 yards on the ground and had three players to rush for more than 100 yards.
Yet, as late as the 7:02 mark of the third frame the Indians were still very much in the game, trailing 37-34.
The Lions made their move when Enrique Garza picked off Jacksonville quarterback Patrick Clater, enabling the visitors to set up shop on the 50-yard line.
Henderson needed just four plays for Jakobie Bussey to juke into the end zone from 10-yards out, which gave Henderson a 44-34 advantage. Bussey carried five times for 101 yards in the tilt.
Things continued to go the Lions' way when Clater was called for intentional grounding on a pass that was released in the end zone, which, by rule, resulted in a safety.
Henderson added another touchdown with 3:51 left in the third to go up 53-34, which proved to be too
much for the Tribe to overcome.
The Indians trailed 30-20 at halftime and were able to slice the Lion lead to 30-27 following a 19-yard scoring strike from Clater to Tyress Gipson that came with 9:57 to play in the third.
Clater went 11-21-1 via the skies and passed for 214 yards and three touchdowns. He netted 26 yards on 12 carries on the ground and was Jacksonville's leading rusher, but was sacked three times for a loss of 29 yards.
Colorado-commit Chris Carpenter also tossed a touchdown pass. He dialed up Jaylon Freeney from 29 yards outs in the second quarter.
As a receiver Carpenter was held to five catches for 78 yards and one touchdown.
Henderson quarterback Caleb Medford led his team in rushing (11-138) and scored one touchdown).
Kevin Fields tacked on 129 yards on 11 carries.
Kasey Canady and Steven Gallegos had fumble recoveries for the Indians.
The Lions had 637 total yards compared to Jacksonville's 325.
NOTE: Chris Carpenter (king) and Brandi Diaz (queen) were elected as Jacksonville royalty and were crowned on the field prior to the start of the game.